Illumina is recruiting a talented experimental scientist to develop massively parallel sequencing assays for measuring the functional effects of millions of human genetic variants. Methods employed may include CRISPR, MPRA, single cell RNA-seq, splicing assays, and other novel approaches to experimentally perturb large numbers of genetic variants, with the aim of functionally validating millions of variants from exome and whole genome sequencing of disease cohorts. This is an opportunity to work on fundamental science with the backing of Illumina’s resources for data generation. Findings will be published in peer-reviewed journals and released in software products in order to improve the accuracy, throughput, and reproducibility of genome interpretation, thereby removing barriers to clinical adoption of whole genome sequencing. In addition to strong analytical skills, this position will require a high degree of initiative, autonomy, and scientific collaboration.
Exceptional collaboration and teamwork skills and track record of technical achievement
Design and execute experimental approaches for saturation mutagenesis or deep mutational scanning of protein coding genes or non-coding elements and splicing regulatory elements.
Expertise in molecular biology techniques (RNA and DNA extraction, vector design, cloning, PCR optimization etc), CRISPR based genome editing, Lentiviral packaging and transduction, cell culture, transfection, FACS, single cell sequencing.
Experience with NGS datasets analysis and comfortable using command-line tools. Familiar with statistical analysis using tools such as JMP, R or similar.
Publish and present results to benefit the wider genetics community.
Positions are available now in the SF Bay Area, California, US. Principal investigator contact: email@example.com
You will have the opportunity of working within the worlds leading team regarding genomes, we hold the largest publications and you will join the Research Technology and Development team where the blue-sky thinking happens.
With Illumina you can expect a highly competitive salary accompanied by a market leading benefits package. You will be part of the global leader in the Sequencing industry where you will find robust growth opportunities and career development within Illumina.
Our team members are bright, energetic, and dedicated—they are the driving force behind our innovation and impact. To attract the best and brightest, we offer a competitive employee benefits program. We view it as a smart investment in our people, one that recognizes the tremendous value they bring to our business every day. At Illumina, we push boundaries. We think beyond the conventional. We dream big. With the energy of so many bright and accomplished people, the opportunities are endless.