CDC Postdoctoral Fellowship in Molecular Genetics/Genomics - Translational
Oak Ridge Institute for Science and Education (ORISE)
Location: Atlanta, Georgia
Type: Full Time
Salary: Monthly Stipend TBD
Years of Experience:
Less than 2
The participant will receive a monthly stipend commensurate with educational level and experience.
Internal Number: CDC-NCEZID-DHCPP-2022-027
*Applications will be reviewed on a rolling-basis.
CDC Office and Location: A fellowship opportunity is available in the National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of High-Consequence Pathogens and Pathology (DHCPP), Chronic Viral Diseases Branch (CVDB) at the Centers for Disease Control and Prevention (CDC) located in Atlanta, Georgia.
The Centers for Disease Control and Prevention (CDC) is one of the major operation components of the Department of Health and Human Services. CDC works to protect America from health, safety and security threats, both foreign and in the U.S. Whether diseases start at home or abroad, are chronic or acute, curable or preventable, human error or deliberate attack, CDC fights disease and supports communities and citizens to do the same.
Research Project: Under the guidance of a mentor, the selected candidate will participant with projects related to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). S/he will participate with multi-site clinical studies, biorepository establishment, and development of specimen management databases, specimen processing, molecular testing, sequence and data analyses, and laboratory quality management system.
Learning Objectives: Specific training opportunities may include:
Advance knowledge of ME/CFS pathogenesis using state of the art technologies in genotyping, gene expression and epigenetic (methylation, microRNAs) studies
Develop/implement simplified approaches for identification and validation of molecular targets of diagnostic, or therapeutic value
Identification of molecular/biological subtypes of ME/CFS that have genetic underpinning with quantitative trait loci QTLs) associated with gene expression (eQTL), protein (pQTL) or metabolites QTL and applying appropriate genetic statistical modeling/bioinformatics/computational knowledge
Management of biorepository databases like Freezerworks. This can involve building adequate IT infrastructure to track and monitor specimen location, handling, processing, checking-in and checking-out of biological materials and associated data sets representing several large-scale case-control and longitudinal studies. Develop specimen life-cycle attributes with the knowledge of relational database structure
Participate in assay optimization and development to carry out molecular epidemiologic studies, that may be focused on pathways involved with neuroimmune regulation, inflammation and ion channels and transporters
Cataloguing, processing, and storing biologic samples while observing all safety guidelines
Nucleic acid extraction (DNA and RNA), purification and evaluation of quality
Documentation of laboratory activities, data, summaries
Quality control and safety procedures necessary for the performance of laboratory protocols and working with biohazard materials
Participate in laboratory quality management activities
Participate in the weekly Branch meetings
Mentor(s): The mentor(s) for this opportunity is Mangalathu S. Rajeevan (firstname.lastname@example.org). Please contact them if you have questions about the nature of this research.
Anticipated Appointment Start Date: September 15, 2022. Start date is flexible and will depend on a variety of factors.
Appointment Length: The appointment will initially be for one year, but may be renewed upon recommendation of CDC and is contingent on the availability of funds.
Level of Participation: The appointment is full-time.
Participant Stipend: The participant will receive a monthly stipend commensurate with educational level and experience.
Citizenship Requirements: This opportunity is available to U.S. citizens and Lawful Permanent Residents (LPR).
ORISE Information: This program, administered by ORAU through its contract with the U.S. Department of Energy (DOE) to manage the Oak Ridge Institute for Science and Education (ORISE), was established through an interagency agreement between DOE and CDC. Participants do not become employees of CDC, DOE or the program administrator, and there are no employment-related benefits. Proof of health insurance is required for participation in this program. Health insurance can be obtained through ORISE.
The successful applicant(s) will be required to comply with Environmental, Safety and Health (ES&H) requirements of the hosting facility, including but not limited to, COVID-19 requirements (e.g. facial covering, physical distancing, testing, vaccination).
Questions: Please visit our Program Website. After reading, if you have additional questions about the application process please email ORISE.CDC.NCEZID@orau.org and include the reference code for this opportunity.
The qualified candidate should have received a doctoral degree in one of the relevant fields (e.g. Molecular Biology). Degree must have been received within five years of the appointment start date.
Some experience in translational research using approaches and tools of genomics/molecular genetics
Prior experience with biorepository establishment, database structure and management
Prior experience with molecular biology methods including next generation sequencing, and in the use of bioinformatics pipeline
Familiarity with biological pathways
Citizenship: LPR or U.S. Citizen
Degree: Doctoral Degree received within the last 60 month(s).
About Oak Ridge Institute for Science and Education (ORISE)
The Oak Ridge Institute for Science and Education is a U.S. Department of Energy asset that is dedicated to enabling critical scientific, research, and health initiatives of the department and its laboratory system by providing world class expertise in STEM workforce development, scientific and technical reviews, and the evaluation of radiation exposure and environmental contamination.
ORISE accomplishes its mission by providing superior, integrated solutions to:
Recruit and prepare the next generation of our nation’s scientific workforce
Promote sound scientific and technical investment decisions through independent peer reviews
Facilitate and prepare for the medical management of radiation incidents in the United States and abroad
Evaluate health outcomes in individuals exposed to chemical and radiological hazards
Ensure public confidence in environmental cleanup through independent environmental assessments
ORISE performs this work for DOE and its national laboratory system and for non-DOE entities through the Strategic Partnership Projects program.